Abstract | BACKGROUND: OBJECTIVE: the aim of this study was to evaluate the value of monocyte measurements in predicting flares in inflammatory bowel disease patients under maintenance treatment with anti-TNF. METHODS: a prospective, observational cohort study was designed. Relapse was defined as a Harvey-Bradshaw score > 4 in Crohn's disease, and a partial Mayo score ≥ 2 in ulcerative colitis. Monocyte concentration was quantified at 4-month intervals for twelve months. A total of 95 consecutive patients were included. Median age was 42 years, 50.5 % were female, and 75 % had Crohn's disease. RESULTS: sixteen months after inclusion, 65 (68.4 %) patients remained in clinical remission. Mean monocyte count preceding a relapse was 563 (standard deviation: 144) compared to 405 (standard deviation: 177) in patients who remained in remission. Final monocyte count was significantly different between relapse and remission in Crohn's disease (0.82; 95 % CI: 0.71-0.90; p < 0.005). According to the multivariate analysis, only monocytes and fecal calprotectin were related to more relapses. CONCLUSION:
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Authors | Rocío Ferreiro-Iglesias, Manuel Barreiro-de Acosta, Javier López-Díaz, Iria Bastón Rey, Juan Enrique Domínguez-Muñoz |
Journal | Revista espanola de enfermedades digestivas
(Rev Esp Enferm Dig)
Vol. 114
Issue 1
Pg. 10-15
(01 2022)
ISSN: 1130-0108 [Print] Spain |
PMID | 33486959
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Leukocyte L1 Antigen Complex
- Tumor Necrosis Factor Inhibitors
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Topics |
- Adult
- Cohort Studies
- Colitis, Ulcerative
(drug therapy)
- Crohn Disease
(drug therapy)
- Feces
(chemistry)
- Female
- Humans
- Inflammatory Bowel Diseases
(drug therapy)
- Leukocyte L1 Antigen Complex
(analysis)
- Longitudinal Studies
- Male
- Monocytes
(chemistry)
- Prospective Studies
- Recurrence
- Remission Induction
- Tumor Necrosis Factor Inhibitors
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