TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism.

Abstract

This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.

• Authors: Stephanie Graser, Daniel Liedtke, Franz Jakob
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 2 (Jan 18 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 33477631 (Publication Type: Journal Article, Review)

Chemical References

• ALPL protein, human
• Alkaline Phosphatase

Topics

• Alkaline Phosphatase (genetics)
• Animals
• Calcification, Physiologic (genetics)
• Disease Models, Animal
• Humans
• Hypophosphatasia (genetics, pathology)
• Mice
• Mutation
• Rare Diseases (genetics, pathology)