The colossal role of H-MnO2-PEG in ischemic stroke.

Abstract

Stroke is one of the most serious problems that seriously affect people's health and brings huge economic burden to society. The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In recent years, nano drug delivery system has developed rapidly and applied to treat ischemic stroke. Here, we report the synthesis and functionalization of monodisperse hollow structured MnO2 (H-MnO2). The highly monodisperse H-MnO2 with uniform morphology was obtained by in situ growing MnO2 on solid silica nanoparticles and subsequently removing the silica core. After successive modification of poly ethylene glycol(PEG), we further verified their protective effect on ischemic stroke in our study.

• Authors: Song-Bin Yang, Xiao-Liu Li, Kai Li, Xin-Xin Zhang, Mei Yuan, Yi-Sha Guo, Xia Bi
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 33 Pg. 102362 (04 2021) ISSN: 1549-9642 [Electronic] United States
• PMID: 33476765 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Manganese Compounds
• Nanoparticle Drug Delivery System
• Oxides
• Polyethylene Glycols
• manganese oxide
• Silicon Dioxide

Topics

• Animals
• Apoptosis (drug effects)
• Behavior, Animal
• Disease Models, Animal
• Drug Liberation
• Humans
• Infarction, Middle Cerebral Artery (drug therapy)
• Male
• Manganese Compounds (chemistry)
• Morris Water Maze Test
• Nanoparticle Drug Delivery System (administration & dosage, adverse effects, chemistry)
• Oxides (chemistry)
• Polyethylene Glycols (chemistry)
• Rats
• Rats, Sprague-Dawley
• Silicon Dioxide (chemistry)
• Surface Properties