Abstract | BACKGROUND AND OBJECTIVES: METHODS: T2DM patients who had undertaken dietary therapy alone or in combination with drug therapy using miglitol for ≥ 8 weeks and healthy volunteers were subjected to a meal tolerance test and glucose concentration, neutrophil elastase concentration, and mRNA expression analyses of peripheral leukocytes by microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) immediately before and 180 min after a meal. RESULTS:
Blood glucose concentrations 60 min after a meal were lower in T2DM patients with dietary + miglitol therapy than in those with dietary therapy alone. Neutrophil elastase concentrations at 60 and 120 min after a meal were lower in T2DM patients with dietary + miglitol therapy than in those with dietary therapy alone. Expression levels of S100A8 in a fasting state and S100A6, S100A8, and S100A9 180 min after a meal were higher in T2DM patients with dietary therapy alone than in healthy volunteers. Expression levels of S100A12 in a fasting state and 180 min after a meal were higher in T2DM patients with dietary therapy alone than in T2DM patients with dietary + miglitol therapy. CONCLUSIONS: S100 genes were more highly expressed in T2DM patients with dietary therapy than in healthy volunteers.
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Authors | Shinnosuke Kondo, Kazuki Mochizuki, Natsuyo Hariya, Miyoko Saito, Satako Doguchi, Takeshi Osonoi |
Journal | Drugs in R&D
(Drugs R D)
Vol. 21
Issue 1
Pg. 91-101
(Mar 2021)
ISSN: 1179-6901 [Electronic] New Zealand |
PMID | 33464544
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Cytokines
- Hypoglycemic Agents
- RNA, Messenger
- S100 Proteins
- miglitol
- 1-Deoxynojirimycin
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Topics |
- 1-Deoxynojirimycin
(analogs & derivatives, therapeutic use)
- Adult
- Aged
- Cytokines
(genetics, metabolism)
- Diabetes Mellitus, Type 2
(blood, diet therapy, drug therapy)
- Fasting
(blood)
- Female
- Gene Expression Regulation
- Hospitals, University
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Inflammation
(genetics, metabolism)
- Leukocytes
(metabolism)
- Male
- Middle Aged
- Prospective Studies
- RNA, Messenger
(analysis)
- S100 Proteins
(genetics, metabolism)
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