Abstract | OBJECTIVE: METHODS: A systematic research of multiple databases was performed to identify relevant studies, and the studies satisfying the inclusion criteria were included. Risk ratio (RR), weighted mean difference (WMD), and 95% confidence intervals were calculated using RevMan 5.3. RESULTS: 2937 patients from 10 studies who were enrolled in this meta-analysis were divided into the Seprafilm group (n = 1334) and the control group (n = 1603). The Seprafilm group had lower incidence of intestinal obstruction (RR, 0.52; 95% CI, 0.38-0.70; p < .0001), reoperation rates due to intestinal obstruction (RR, 0.48; 95% CI, 0.28 - 0.80; p = .005), incidence of overall complications (RR, 0.77; 95% CI, 0.61-0.97; p = .03) and higher serum creatinine on postoperative day 5 (WMD, 0.15; 95% CI, 0.05-0.25; p = .003). There were no differences regarding time to intestinal obstruction after operation, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, white blood cell count results on day 5 and 7, serum creatinine on day 7, hospital stay, and incidence of intra-abdominal infection, wound infection, anastomotic leakage between the 2 groups. CONCLUSIONS:
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Authors | Jiefeng Zhao, Chao Huang, Jisheng Zhu, Jinfeng Zhu, Rongfa Yuan, Zhengming Zhu |
Journal | Acta chirurgica Belgica
(Acta Chir Belg)
Vol. 121
Issue 1
Pg. 1-15
(Feb 2021)
ISSN: 0001-5458 [Print] England |
PMID | 33459577
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Chemical References |
- Seprafilm
- Hyaluronic Acid
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Topics |
- Digestive System Surgical Procedures
- Gastrointestinal Neoplasms
(surgery)
- Humans
- Hyaluronic Acid
(therapeutic use)
- Intestinal Obstruction
(etiology, prevention & control)
- Multicenter Studies as Topic
- Postoperative Complications
(epidemiology, prevention & control)
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