Abstract | BACKGROUND: METHODS: RESULTS: No signs of recovery were found in the untreated animals. After InSurE, oxygenation improved more rapidly compared to LISA. However, at 180' LISA and InSurE showed comparable outcomes in terms of gas exchange, ventilation parameters, and lung mechanics. Neither DSPC in the alveolar pool nor SP-C signal distributions in a frontal lung section were significantly different between InSurE and LISA groups. CONCLUSIONS: In an acute setting, LISA demonstrated efficacy and surfactant lung delivery similar to that of InSurE in surfactant-depleted adult rabbits. IMPACT: Although LISA technique is gaining popularity, there are still several questions to address. This is the first study comparing LISA and InSurE in terms of gas exchange, ventilation parameters, and lung mechanics as well as surfactant deposition and distribution. In our animal study, three hours post-treatment, LISA method seems to be as effective as InSurE and showed similar surfactant lung delivery. Our findings provide some clarifications on a fair comparison between LISA and InSurE techniques, particularly in terms of surfactant delivery. They should reassure some of the concerns raised by the clinical community on LISA adoption in neonatal units.
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Authors | Francesca Ricci, Ilia Bresesti, Paola Azzurra Maria LaVerde, Fabrizio Salomone, Costanza Casiraghi, Arianna Mersanne, Matteo Storti, Chiara Catozzi, Laura Tigli, Riccardo Zecchi, Pietro Franceschi, Xabier Murgia, Manuela Simonato, Paola Cogo, Virgilio Carnielli, Gianluca Lista |
Journal | Pediatric research
(Pediatr Res)
Vol. 90
Issue 3
Pg. 576-583
(09 2021)
ISSN: 1530-0447 [Electronic] United States |
PMID | 33452472
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. |
Chemical References |
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Topics |
- Animals
- Continuous Positive Airway Pressure
- Disease Models, Animal
- Humans
- Pulmonary Surfactants
(administration & dosage)
- Rabbits
- Respiration, Artificial
- Respiratory Distress Syndrome, Newborn
(drug therapy)
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