Abstract | BACKGROUND: METHODS: Of the 502 subjects who underwent both echocardiography and PWV measurement in a medical check-up conducted in Arita, Japan, we enrolled 262 consecutive normotensive subjects (age 52 ± 13 years). LV diastolic dysfunction was defined as abnormal relaxation and pseudonormal or restrictive patterns determined with both transmitral flow velocity and mitral annular velocity. Aortic stiffness was assessed via non-invasive brachial-ankle PWV measurement. RESULTS:
LV diastolic dysfunction was detected in 67 of the 262 (26%) normotensive subjects, and PWV was higher in subjects with LV diastolic dysfunction (15.4 ± 3.6 vs. 13.0 ± 2.7 m/s, p < 0.01). Multivariate logistic regression analyses revealed that PWV was independently associated with LV diastolic dysfunction (p = 0.02) after the adjustment for age; body mass index; blood pressure; eGFR; blood levels of BNP, glucose, and HDL cholesterol; LV mass index; and LA dimension. CONCLUSIONS: Both aortic stiffness and LV diastolic function are mutually related even in normotensive subjects, independent of the potential confounding factors. The increase in aortic stiffness may be a risk factor for LV diastolic dysfunction, irrespective of blood pressure.
|
Authors | Maeda Mika, Hideaki Kanzaki, Takuya Hasegawa, Hiroki Fukuda, Makoto Amaki, Jiyoong Kim, Masanori Asakura, Hiroshi Asanuma, Motonobu Nishimura, Masafumi Kitakaze |
Journal | International Journal of Cardiology. Hypertension
(Int J Cardiol Hypertens)
Vol. 6
Pg. 100038
(Sep 2020)
ISSN: 2590-0862 [Electronic] Netherlands |
PMID | 33447764
(Publication Type: Journal Article)
|
Copyright | © 2020 The Authors. |