Severe Non-Islet Cell Hypoglycemia From Ileum-Origin Gastrointestinal Stromal Tumor Producing Insulin-Like Growth Factor-2 in a Patient With Liver Cirrhosis Due to Chronic Hepatitis B.

Abstract

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome, and NICTH associated with gastrointestinal stromal tumor (GIST) is even more rare. Herein, we describe a patient with severe NICTH due to GIST who had developed liver cirrhosis as a consequence of chronic hepatitis B. Although circulating insulin, C-peptide, and insulin-like growth factor-1 (IGF-1) levels were significantly decreased, in contrast to our expectations, the growth hormone (GH) level was slightly elevated. Steroid therapy with prednisolone appeared to be effective for the prevention of severe and continuous hypoglycemia.

• Authors: Kohzo Takebayashi, Sho Furukawa, Takenori Okumura, Mio Kubo, Atsushi Ujiie, Mototaka Yamauchi, Hiroyuki Shinozaki, Kenji Hara, Takafumi Tsuchiya, Yuko Ono, Toshihiko Inukai, Koshi Hashimoto
• Journal: Journal of clinical medicine research (J Clin Med Res) Vol. 12 Issue 12 Pg. 824-830 (Dec 2020) ISSN: 1918-3003 [Print] Canada
• PMID: 33447317 (Publication Type: Case Reports)
• Copyright: Copyright 2020, Takebayashi et al.