| Abstract |
In a recent issue of Cell, Bowling et al. describe a mechanism by which spliceosome-targeted therapies result in intron-containing transcripts that form double-stranded RNAs (dsRNAs), thereby activating tumor antiviral signaling (viral mimicry) and downstream adaptive immunity. |
| Authors | Charles A Ishak, Helen Loo Yau, Daniel D De Carvalho |
| Journal | Immunity
(Immunity)
Vol. 54
Issue 1
Pg. 11-13
(01 12 2021)
ISSN: 1097-4180 [Electronic] United States |
| PMID | 33440135
(Publication Type: Journal Article, Comment)
|
| Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
| Chemical References |
- Antiviral Agents
- RNA, Double-Stranded
|
| Topics |
- Adaptive Immunity
- Antiviral Agents
(pharmacology)
- RNA, Double-Stranded
- Signal Transduction
(drug effects)
- Spliceosomes
|
