Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response.

Abstract

Phosphorylcholine monoclonal immunoglobulin G antibody attenuates the immediate post-ischemic inflammatory response by reducing the proinflammatory chemokine (C-C motif) ligand 2 chemokine and circulating Ly-6Chi monocytes. This subsequently enhances the post-ischemic repair process, resulting in limited adverse cardiac remodeling and preservation of cardiac function. Therefore, phosphorylcholine monoclonal immunoglobulin G antibody therapy may be a valid therapeutic approach against myocardial ischemia-reperfusion injury.

• Authors: Niek J Pluijmert, Rob C M de Jong, Margreet R de Vries, Knut Pettersson, Douwe E Atsma, J Wouter Jukema, Paul H A Quax
• Journal: JACC. Basic to translational science (JACC Basic Transl Sci) Vol. 5 Issue 12 Pg. 1228-1239 (Dec 2020) ISSN: 2452-302X [Electronic] United States
• PMID: 33426378 (Publication Type: Journal Article)
• Copyright: © 2020 The Authors.