Abstract | OBJECTIVE: METHODS: A total of 30 patients with VLSA who failed routine treatment were treated with ALA- PDT. The patients were irradiated at a power density of 60-90 mW/cm2 with a red light at a wavelength of 635±15 nm for 20 min. Twenty percent of ALA water-in-oil emulsion was applied to the lesion and sealed with plastic film for 3 h. The treatment was repeated three times every 2 weeks. The objective and subjective symptoms and signs of vulvar lesions based on the horizontal visual analogue scale were recorded at 6 months after each treatment and the last treatment. RESULTS: All patients completed three cycles of ALA- PDT and follow-up. The clinical symptoms of pruritus completely disappeared in 27 cases. Itching changed from severe to mild in three cases. The pathological changes of all subjects were improved. The main side effects of ALA- PDT were pain, erythema, and swelling. The side effects were temporary and tolerable. All patients reported their results as "satisfied" or "very satisfied". CONCLUSIONS: ALA- PDT was an effective and safe approach for the treatment of VLSA.
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Authors | Fenghua Zhang, Daoyun Li, Lijuan Shi, Yijia Gu, Yun Xu |
Journal | International journal of clinical and experimental pathology
(Int J Clin Exp Pathol)
Vol. 13
Issue 12
Pg. 3100-3110
( 2020)
ISSN: 1936-2625 [Electronic] United States |
PMID | 33425110
(Publication Type: Journal Article)
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Copyright | IJCEP Copyright © 2020. |