A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases.

Abstract

Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti-angiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases.

• Authors: Sanjucta Adak, Damaris Magdalene, Saurabh Deshmukh, Dipankar Das, Bithiah Grace Jaganathan
• Journal: Stem cell reviews and reports (Stem Cell Rev Rep) Vol. 17 Issue 4 Pg. 1154-1173 (08 2021) ISSN: 2629-3277 [Electronic] United States
• PMID: 33410097 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Topics

• Exosomes
• Humans
• Immunomodulation
• Mesenchymal Stem Cells (cytology)
• Retina (cytology)
• Retinal Degeneration (therapy)