Expression and prognostic characteristics of m5 C regulators in low-grade glioma.
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| Abstract |
Glioma is the most common intracranial malignant tumour. A clear diagnosis and molecular targeted therapy are of great significance for improving the survival time and quality of life of patients with low-grade glioma. 5-methylcytosine methylation is one of the ways of RNA modification, but there are limited studies on the role of m5 C methylation of low-grade glioma. Single-nucleotide variant, RNA expression matrix and corresponding clinical data of low-grade glioma came from public database. The single-nucleotide variant and expression of m5 C regulators were estimated. A prognostic model based on m5 C regulators was constructed by Cox regression. Potential functions of these molecules were assessed by gene set enrichment analysis. DNMT3A mutation was the most frequent among the m5 C regulators in low-grade glioma. NSUN3, TET2, TRDMT1, ALYREF, DNMT3B, DNMT1, NOP2 and NSUN2 were up-regulated. One prognostic model was constructed which had a strong predictive power for the overall survival of low-grade glioma. We studied the expression and prognostic characteristics of m5 C regulators in low-grade glioma, supplied biomarkers for the diagnosis and prognosis and provided the foundation for the study of the pathogenesis of low-grade glioma.
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| Authors | Xiaozhi Li, Yutong Meng |
| Journal | Journal of cellular and molecular medicine (J Cell Mol Med) Vol. 25 Issue 3 Pg. 1383-1393 (02 2021) ISSN: 1582-4934 [Electronic] England |
| PMID | 33400376 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. |
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