Combination Tripeptide/Hexapeptide Serum with 1540 nm Nonablative Fractional Laser for the Treatment of Striae Distensae: A Pilot Study.

Abstract

Striae distensae (SD) are associated with negative psychosocial effects. Improvements have been shown with non-ablative fractional lasers (NAFL). Topical peptides have also been effective in cutaneous rejuvenation; however, no studies have examined combination therapy for striae. Our study evaluated the efficacy and safety of a peri-procedural tripeptide/hexapeptide serum as an adjunct to 1540 nm NAFL for the treatment of SD in 10 patients. All patients reported subjective improvement. The addition of tripeptide/hexapep-tide serum increased the objective improvement, reduced the incidence of post-inflammatory hyperpigmentation, and increased patient satisfaction.

• Authors: Kathleen P McGuinn, Nicholas A Ross, Jordan V Wang, Nazanin Saedi
• Journal: Skinmed (Skinmed) Vol. 18 Issue 6 Pg. 337-341 ( 2020) ISSN: 1751-7125 [Electronic] United States
• PMID: 33397562 (Publication Type: Journal Article)

Chemical References

• Dermatologic Agents
• Oligopeptides
• glycyl-histidyl-lysine
• acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide

Topics

• Adult
• Combined Modality Therapy
• Dermatologic Agents (therapeutic use)
• Female
• Humans
• Low-Level Light Therapy (methods)
• Male
• Oligopeptides (therapeutic use)
• Patient Satisfaction
• Pilot Projects
• Striae Distensae (therapy)
• Treatment Outcome