Analysis of the TCGA Dataset Reveals that Subsites of Laryngeal Squamous Cell Carcinoma are Molecularly Distinct.

Abstract

Laryngeal squamous cell carcinoma (LSCC) from different subsites have distinct presentations and prognosis. In this study, we carried out a multiomic comparison of LSCC subsites. The Cancer Genome Atlas (TCGA) LSCC cohort was analyzed in the R statistical environment for differences between supraglottic and glottic cancers in single nucleotide variations (SNVs), copy number alterations (CNAs), mRNA abundance, protein abundance, pathway overrepresentation, tumor microenvironment (TME), hypoxia status, and patient outcome. Supraglottic cancers had significantly higher overall and smoking-associated SNV mutational load. Pathway analysis revealed upregulation of muscle related pathways in glottic cancer and neural pathways in supraglottic cancer. Proteins involved in cancer relevant signaling pathways including PI3K/Akt/mTOR, the cell cycle, and PDL1 were differentially abundant between subsites. Glottic and supraglottic tumors have different molecular profiles, which may partially account for differences in presentation and response to therapy.

• Authors: Alana Sorgini, Hugh Andrew Jinwook Kim, Peter Y F Zeng, Mushfiq Hassan Shaikh, Neil Mundi, Farhad Ghasemi, Eric Di Gravio, Halema Khan, Danielle MacNeil, Mohammed Imran Khan, Adrian Mendez, John Yoo, Kevin Fung, Pencilla Lang, David A Palma, Joe S Mymryk, John W Barrett, Krupal B Patel, Paul C Boutros, Anthony C Nichols
• Journal: Cancers (Cancers (Basel)) Vol. 13 Issue 1 (Dec 31 2020) ISSN: 2072-6694 [Print] Switzerland
• PMID: 33396315 (Publication Type: Journal Article)