Abstract |
Thirteen patients who developed malignant progression after frequent recurrence of noninvasive or superficially invasive (Ta or T1) papillary transitional cell carcinoma of the bladder were studied for expression of ABH- antigens in tumor tissues throughout their clinical courses and cryptic Thomsen-Friedenreich antigen (T-Ag) expression in the tumor tissues was examined simultaneously in nine of them. Five patients who experienced recurrent bladder tumors for more than 5 years without any malignant progression were served as control. ABH- antigens in initial tumors were negative in only two of 13 patients developing malignant progression and in two of five controls. Cryptic T-Ag was positive in all patients examined. Recurrent tumors revealed eliminated or decreased expression of ABH- antigens and cryptic T-Ag before malignant progression in, respectively, ten of 11 and six of nine patients with antigen-positive initial tumors. In contrast, recurrent tumor of controls with antigen-positive initial tumors showed neither elimination nor decrease in expression of antigens throughout their clinical courses.
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Authors | T Yamada, I Fukui, M Yokokawa, H Oshima |
Journal | Cancer
(Cancer)
Vol. 61
Issue 4
Pg. 721-6
(Feb 15 1988)
ISSN: 0008-543X [Print] United States |
PMID | 3338034
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ABO Blood-Group System
- Antigens, Tumor-Associated, Carbohydrate
- Isoantigens
- Thomsen-Friedenreich antigen
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Topics |
- ABO Blood-Group System
- Adult
- Aged
- Antigens, Tumor-Associated, Carbohydrate
(analysis)
- Carcinoma, Transitional Cell
(immunology, pathology)
- Female
- Humans
- Isoantigens
(analysis)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Prognosis
- Urinary Bladder Neoplasms
(immunology, pathology)
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