Novel Perspectives Regarding the Pathology, Inflammation, and Biomarkers of Acute Respiratory Distress Syndrome.

Abstract

Acute respiratory distress syndrome (ARDS) is an acute inflammation of the lung resulting from damage to the alveolar-capillary membrane, and it is diagnosed using a combination of clinical and physiological variables. ARDS develops in approximately 10% of hospitalised patients with pneumonia and has a mortality rate of approximately 40%. Recent research has identified several biomarkers associated with ARDS pathophysiology, and these may be useful for diagnosing and monitoring ARDS. They may also highlight potential therapeutic targets. This review summarises our current understanding of those clinical biomarkers: (1) biomarkers of alveolar and bronchiolar injury, (2) biomarkers of endothelial damage and coagulation, and (3) biomarkers for treatment responses.

• Authors: Pradeesh Sivapalan, Barbara Bonnesen, Jens-Ulrik Jensen
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 1 (Dec 28 2020) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 33379178 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers

Topics

• Animals
• Biomarkers (blood)
• Blood Coagulation
• Bronchi (metabolism)
• Endothelium, Vascular (metabolism)
• Humans
• Pulmonary Alveoli (metabolism)
• Respiratory Distress Syndrome (metabolism, therapy)