The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis.
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| Abstract | PURPOSE: The prognostic value of a new scoring system, termed F-NLR, that combines pretreatment fibrinogen level with neutrophil-lymphocyte ratio has been evaluated in various cancers. However, the results are controversial. The purpose of this study was to comprehensively analyze the prognostic value of F-NLR score in patients with cancers. METHODS: An integrated search of relevant studies was conducted by screening the PubMed and Embase databases. Pooled hazard ratios, with 95% confidence intervals (CIs), for overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS) were calculated to estimate the prognostic significance of F-NLR score in patients with various tumors. A random effects model was used for comprehensive analysis, and subgroup and meta-regression analyses were used to explore sources of heterogeneity. RESULTS: Thirteen articles reporting data from of 4747 patients were included in the study. Pooled analysis revealed that high F-NLR score was significantly associated with poor OS (HR = 1.77; 95% CI, 1.51-2.08) and poor DFS/PFS (HR = 1.63; 95% CI, 1.30-2.05). Subgroup and meta-regression analyses did not alter the prognostic role of F-NLR score in OS and DFS/PFS. CONCLUSIONS:
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| Authors | Rongqiang Liu, Shiyang Zheng, Qing Yuan, Peiwen Zhu, Biao Li, Qi Lin, Wenqing Shi, Youlan Min, Qianmin Ge, Yi Shao |
| Journal | Disease markers (Dis Markers) Vol. 2020 Pg. 4565379 ( 2020) ISSN: 1875-8630 [Electronic] United States |
| PMID | 33376559 (Publication Type: Journal Article, Meta-Analysis, Systematic Review) |
| Copyright | Copyright © 2020 Rongqiang Liu et al. |
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