Lipid accumulation product is a reliable indicator for identifying metabolic syndrome: the China Multi-Ethnic Cohort (CMEC) Study.

Abstract

BACKGROUND:

Previous studies have shown that lipid accumulation product (LAP) was associated with the risk of cardiometabolic disease. It is not clear whether LAP could be used as a marker to identify metabolic syndrome (MetS) among Chinese ethnic groups.

AIM:

To assess the reliability of LAP as a maker to identify MetS among Dong adults.

DESIGN:

Population-based cross-sectional study.

METHOD:

We included 6494 Dong individuals (1403 patients) aged 30-79 years from southwest China. MetS was established by Chinese Diabetes Society. Logistic regression model was utilized to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Receiver operating characteristic (ROC) curve was utilized to calculate area under the ROC curve (AUC) and 95% CIs to obtain the identification ability for MetS.

RESULTS:

The risk of MetS was increased with per 5 units increase of LAP (OR 1.37 [95% CI, 1.34-1.39]). Similar results were found in subgroup analyses and sensitivity analyses. Clustered metabolic risk associated with per 5 units increase of LAP was observed for people with 1 (OR 1.59 [95% CI, 1.53-1.65]), 2 (2.15 [2.06-2.24]), 3 (2.59 [2.48-2.71]), 4 (2.81 [2.69-2.95]) and 5 (3.03 [2.87-3.21]) MetS components. LAP presented higher AUC (0.915 [95% CI, 0.907-0.923]) than other included obesity indices (P < 0.05).

CONCLUSION:

These data support evidence that LAP was related to the risk of MetS, had a high AUC and could be a reliable index for identifying MetS patients among Dong adults in Chinese.

• Authors: X Zhang, F Hong, L Liu, F Nie, L Du, H Guan, Z Wang, Q Zeng, J Yang, J Wang, X Li, J Zhang, P Luo
• Journal: QJM : monthly journal of the Association of Physicians (QJM) Vol. 115 Issue 3 Pg. 140-147 (Mar 22 2022) ISSN: 1460-2393 [Electronic] England
• PMID: 33367838 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2020. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: [email protected].

Topics

• Adult
• Aged
• Humans
• Middle Aged
• Body Mass Index
• China (epidemiology)
• Cross-Sectional Studies
• Ethnicity
• Lipid Accumulation Product
• Metabolic Syndrome (diagnosis, epidemiology)
• Reproducibility of Results
• Risk Factors
• ROC Curve