Abstract | BACKGROUND AND AIMS: Extra-intestinal manifestations [EIMs] are frequent in patients with inflammatory bowel diseases [IBD] and are challenging conditions to manage. Tumour necrosis factor alpha antagonists [anti-TNFα] are recognised as the primary therapeutic option. We aimed to summarise evidence on the efficacy of ustekinumab for the treatment of EIMs. METHODS: We searched in PubMed, Cochrane Library, and Web of Science, up to October 2020, all interventional and non-interventional studies published in English and assessing ustekinumab efficacy for the treatment of EIMs. RESULTS: CONCLUSIONS:
Ustekinumab showed to be an effective option for the treatment of EIMs, especially for dermatological and rheumatological manifestations. However, more data are needed to confirm the role of ustekinumab in this setting.
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Authors | Lucas Guillo, Ferdinando D'Amico, Silvio Danese, Laurent Peyrin-Biroulet |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 15
Issue 7
Pg. 1236-1243
(Jul 05 2021)
ISSN: 1876-4479 [Electronic] England |
PMID | 33367674
(Publication Type: Journal Article, Review)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: [email protected]. |
Chemical References |
- Dermatologic Agents
- Ustekinumab
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Topics |
- Dermatologic Agents
(therapeutic use)
- Humans
- Inflammatory Bowel Diseases
(complications, drug therapy)
- Ustekinumab
(therapeutic use)
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