Cancer cells are able to undergo aerobic glycolysis and metabolize
glucose to
lactate instead of oxidative phosphorylation, which is known as Warburg effect. Accumulating evidence has revealed that
microRNAs regulate
cancer cell metabolism, which manifest a higher rate of
glucose metabolism. Various signaling pathways along with glycolytic
enzymes are responsible for the emergence of glycolytic dependence.
MicroRNAs are a class of non-coding RNAs that are not translated into
proteins but regulate target gene expression or in other words function pre-translationally and post-transcriptionally.
MicroRNAs have been shown to be involved in various biological processes, including
glucose metabolism via targeting major
transcription factors,
enzymes, oncogenes or
tumor suppressors alongside the oncogenic signaling pathways. In this review, we describe the regulatory role of
microRNAs of
cancer cell
glucose metabolism, including in the
glucose uptake, glycolysis, tricarboxylic acid cycle and several signaling pathways and further suggest that
microRNA-based
therapeutics can be used to inhibit the process of
glucose metabolism reprogramming in
cancer cells and thus suppressing
cancer progression.