Abstract | INTRODUCTION: OBJECTIVE: METHODS: Based on the available literature and the experiences collected from adult and paediatric patients treated in Switzerland, the Working Party on Haemostasis of the Swiss Society of Haematology and the Swiss Haemophilia Network worked together to reach a consensus on the management of bleeding events and invasive procedures. RESULTS AND CONCLUSION: Minor bleeding events and invasive procedures associated with low bleeding risk can be treated without factor replacement therapy in most cases, whereas major bleeding events and high-risk surgery require additional factor VIII replacement at usual doses, at least for the first days. Emicizumab treatment should be continued throughout the procedure and during the postoperative period. Elective major surgery should be planned according to emicizumab dosing for patients with a once-a-month posology. Of note, so far only few data are available on the management of major bleeds and surgery in patients with haemophilia A treated with emicizumab and this practical guidance will have to be regularly updated with growing experience.  .
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Authors | Pierre Fontana, Lorenzo Alberio, Manuela Albisetti, Anne Angelillo-Scherrer, Lars M Asmis, Alessandro Casini, Bernhard Gerber, Lukas Graf, Inga Hegemann, Wolfgang Korte, Maria Martinez, Jan-Dirk Studt, Dimitrios A Tsakiris, Walter A Wuillemin, Johanna A Kremer Hovinga |
Journal | Swiss medical weekly
(Swiss Med Wkly)
Vol. 150
Pg. w20422
(Dec 14 2020)
ISSN: 1424-3997 [Electronic] Switzerland |
PMID | 33338252
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Bispecific
- Antibodies, Monoclonal, Humanized
- emicizumab
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Topics |
- Adult
- Antibodies, Bispecific
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Child
- Hemophilia A
(drug therapy)
- Hemorrhage
(chemically induced)
- Humans
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