Abstract | BACKGROUND: Patients with chronic lung diseases, including cystic fibrosis (CF), are frequently sensitized to Aspergillus fumigatus. Whether patients with non-CF bronchiectasis develop sensitization to A fumigatus remains unknown. OBJECTIVE: To evaluate the prevalence of sensitization and chronic infection with A fumigatus in subjects with bronchiectasis. We also performed a multivariate logistic regression analysis to identify factors predicting sensitization and chronic A fumigatus infection. METHODS: RESULTS: We included 258 subjects (TB [n = 155], idiopathic [n = 66] and other causes [n = 37]) with bronchiectasis. The prevalence of Aspergillus sensitization, chronic Aspergillus infection, and both sensitization and chronic infection was 29.5% (76/258), 76% (196/258) and 26% (68/258), respectively. In a multivariate logistic regression analysis, TB-related bronchiectasis was an independent risk factor for Aspergillus sensitization. Chronic Aspergillus infection was predicted by the duration of symptoms and specific aetiologies ( tuberculosis and idiopathic) of bronchiectasis. The growth of Aspergillus species was also frequent in the TB group compared with other causes (32% vs 2%; P < .001). CONCLUSIONS:
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Authors | Inderpaul Singh Sehgal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Valliappan Muthu, Ashutosh Nath Aggarwal, Amit Rawat, Arnab Pal, Amanjit Bal, Mandeep Garg, Arunaloke Chakrabarti, Ritesh Agarwal |
Journal | Mycoses
(Mycoses)
Vol. 64
Issue 4
Pg. 412-419
(Apr 2021)
ISSN: 1439-0507 [Electronic] Germany |
PMID | 33332671
(Publication Type: Journal Article)
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Copyright | © 2020 Wiley-VCH GmbH. |
Chemical References |
- Immunoglobulin G
- Immunoglobulin E
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Topics |
- Adult
- Aspergillosis
(immunology, microbiology)
- Aspergillosis, Allergic Bronchopulmonary
- Aspergillus fumigatus
(growth & development, immunology)
- Bronchiectasis
(blood, epidemiology, immunology)
- Cystic Fibrosis
- Female
- Humans
- Immunoglobulin E
(blood)
- Immunoglobulin G
(blood)
- India
(epidemiology)
- Logistic Models
- Male
- Middle Aged
- Prevalence
- Prospective Studies
- Sputum
(microbiology)
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