Abstract | OBJECTIVE/BACKGROUND: METHODS: We reviewed outcomes after alloHCT relapse, with or without use of these newer agents for ALL, AML, and MDS. In total, 115 adults with relapsed or refractory ALL (n = 17), AML (n = 67), and MDS (n = 31) at median 5 (range, 1-64) months after their first alloHCT in 2010-2018 were included. RESULTS: Median follow-up was 19 (range, 6-80) months after relapse from alloHCT. Targeted agents were given to 29 (25%) patients. In multivariable analysis, use of targeted agent at any time point after relapse was not associated with survival. Matched unrelated (vs. matched sibling; hazard ratio [HR] 1.70; p = .027) or haploidentical donor grafts (vs. matched sibling; HR 2.69; p = .003), presence of grade II-IV acute graft-versus-host disease before relapse (HR 2.46; p < .001), and less than 12 months from HCT to relapse (<6 vs. > 12 months; HR 6.34; p < .001; 6-12 vs. > 12 months; HR 3.16; p = .005) were adverse prognostic factors for post-relapse survival. CONCLUSION: Outcomes after alloHCT relapse remain poor regardless of the novel agent use. Innovative treatment strategies are needed to improve outcomes after relapse post-alloHCT.
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Authors | Sanghee Hong, Lisa Rybicki, Donna Corrigan, Betty K Hamilton, Ronald Sobecks, Matt Kalaycio, Aaron T Gerds, Rob M Dean, Brian T Hill, Brad Pohlman, Deepa Jagadeesh, Faiz Anwer, Navneet S Majhail |
Journal | Hematology/oncology and stem cell therapy
(Hematol Oncol Stem Cell Ther)
Vol. 14
Issue 4
Pg. 318-326
(Dec 2021)
ISSN: 2589-0646 [Electronic] Saudi Arabia |
PMID | 33301747
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved. |
Topics |
- Hematopoietic Stem Cell Transplantation
- Humans
- Leukemia, Myeloid, Acute
(therapy)
- Myelodysplastic Syndromes
(therapy)
- Recurrence
- Siblings
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