A retrospective study of ulinastatin for the treatment of severe sepsis.

Abstract

This retrospective study aimed to investigate the efficacy and safety of existing approach of ulinastatin for the treatment of severe sepsis (SS).A total of 130 eligible patients with SS were included in this study. We divided them into an intervention group (n = 65) and a control group (n = 65). Patients in both groups received conventional therapy. In addition, patients in the intervention group received ulinastatin for 7 days. Outcomes were measured by Acute Physiology and Chronic Health Evaluation II (APACHE II), Multiple Organ Failure (MOF), Glasgow Coma Scale (GCS), CD3, CD4, CD8, CD4/CD8, and adverse events. We assessed all outcomes before and after treatment.After treatment, patients in the intervention group showed better improvement in APACHE II (P < .01), MOF (P < .01), GCS (P < .01), CD3 (P = .03), CD4 (P = .03), and CD4/CD8 (P < .01), than those of patients in the control group. There are similar safety profiles between both groups.This study suggests that ulinastatin may be beneficial for SS. Future studies are still needed to warrant the results of this study.

• Authors: Chao Meng, Yi Qian, Wen-Hao Zhang, Ying Liu, Xiao-Chun Song, Han Liu, Xiang Wang
• Journal: Medicine (Medicine (Baltimore)) Vol. 99 Issue 49 Pg. e23361 (Dec 04 2020) ISSN: 1536-5964 [Electronic] United States
• PMID: 33285716 (Publication Type: Journal Article, Observational Study)

Chemical References

• Glycoproteins
• Trypsin Inhibitors
• urinastatin

Topics

• APACHE
• Female
• Glasgow Coma Scale
• Glycoproteins (administration & dosage, adverse effects, therapeutic use)
• Humans
• Male
• Multiple Organ Failure
• Retrospective Studies
• Sepsis (drug therapy, immunology)
• Trypsin Inhibitors (administration & dosage, adverse effects, therapeutic use)