Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Acromegaly in Routine Clinical Practice in Germany, Austria and Switzerland.

Abstract

BACKGROUND:

Evidence from controlled trials has shown that lanreotide autogel is effective in achieving biochemical and symptom control in patients with acromegaly. However, it is important to better understand the real-world patient population receiving lanreotide autogel treatment.

METHODS:

In this non-interventional study the long-term treatment response to lanreotide autogel in adult patients with acromegaly from office-based centers or clinics in Germany, Austria and Switzerland was studied. Assessments included growth hormone and insulin-like growth factor-I levels, symptoms, quality of life, lanreotide plasma levels and tumor somatostatin receptor subtype expression. The primary endpoint was achievement of full biochemical control, defined as growth hormone ≤2.5 µg/L and insulin-like growth factor I normalization at month 12.

RESULTS:

76 patients were enrolled from 21 sites. 7/51 (13.7%) patients of the efficacy population had full biochemical control at baseline, 15/33 (45.5%) at month 12 and 10/26 (38.5%) at month 24 of treatment. At 12 months of treatment higher rates of biochemical control were observed in the following subgroups: older patients (>53 years [median]), females, treatment-naïve patients, and patients with a time since diagnosis of longer than 1.4 years (median). No clinically relevant differences in acromegaly symptoms or quality of life scores were observed. Median fasting blood glucose and glycated hemoglobin levels remained unchanged throughout the study. No new safety signals were observed. Overall tolerability of treatment with lanreotide autogel was judged by 80.8% of the enrolled patients at month 12 as 'very good' or 'good'.

CONCLUSION:

Treatment with lanreotide autogel in a real-world setting showed long-term effectiveness and good tolerability in patients with acromegaly.

• Authors: Sylvère Störmann, Jochen Schopohl, Catharina Bullmann, Christoph Terkamp, Mirjam Christ-Crain, Reinhard Finke, Jörg Flitsch, Ilonka Kreitschmann-Andermahr, Anton Luger, Günter Stalla, Aude Houchard, Dorit Helbig, Stephan Petersenn
• Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 129 Issue 3 Pg. 224-233 (Mar 2021) ISSN: 1439-3646 [Electronic] Germany
• PMID: 33285601 (Publication Type: Journal Article, Multicenter Study, Observational Study)
• Copyright: Thieme. All rights reserved.

Chemical References

• Gels
• IGF1 protein, human
• Peptides, Cyclic
• lanreotide
• Human Growth Hormone
• Somatostatin
• Insulin-Like Growth Factor I

Topics

• Acromegaly (blood, drug therapy)
• Adult
• Austria
• Female
• Gels
• Germany
• Human Growth Hormone (blood, drug effects)
• Humans
• Insulin-Like Growth Factor I (drug effects)
• Male
• Middle Aged
• Outcome Assessment, Health Care
• Peptides, Cyclic (administration & dosage, pharmacology)
• Somatostatin (administration & dosage, analogs & derivatives, pharmacology)
• Switzerland