Abstract | OBJECTIVE: To analyze the hematological characteristics of Hb Broomhill and Hb Hornchurch, and prenatal diagnosis should be carried out in two families. METHODS: RBC parameters and hemoglobin electrophoretogram were analyzed on the peripheral blood of all patients, and amniotic fluid was collected for prenatal diagnosis. PCR-Flow fluorescent hybridization and Sanger sequencing were performed for gene diagnosis of thalassemia. RESULTS: Three cases of Hb Broomhill were detected, including 2 cases with common SEA α- thalassemia, which was characterized by hypochromic microcytic mild anemia, the capillary electrophoregram revealed a tiny shoulder peak before the Hb A peak; 1 case was diagnosed as Hb Hornchurch combined with β- thalassemia, which also showed mild anemia. Hemoglobin electrophoretogram showed an abnormal hemoglobin variant peak at Hb A2 zone. CONCLUSION:
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Authors | Ji-Cheng Wang, Hao Guo, Hua-Jie Huang, Teng-Long Yuan, Cui-Ze Yao, Dan-Qing Qin, Li DU |
Journal | Zhongguo shi yan xue ye xue za zhi
(Zhongguo Shi Yan Xue Ye Xue Za Zhi)
Vol. 28
Issue 6
Pg. 2028-2032
(Dec 2020)
ISSN: 1009-2137 [Print] China |
PMID | 33283737
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Anemia, Hypochromic
- Hemoglobins, Abnormal
(genetics)
- Heterozygote
- Humans
- alpha-Thalassemia
(diagnosis, genetics)
- beta-Thalassemia
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