Abstract | BACKGROUND: OBJECTIVE: METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro- brain natriuretic peptide ( NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend <.001). In a subgroup of 2812 patients without pre-existing CHF at baseline, the corresponding aHRs were 1.0, 0.90 (0.47-1.72), 1.69 (0.94-3.04), and 3.48 (1.94-6.24) (P for trend <.001). Patients with IGFBP-7 and NT-proBNP levels above the biomarker-specific median had a higher risk of incident CHF hospitalization (aHR 5.20; 3.35-8.09) compared to those with only 1 elevated marker (elevated IGFBP-7 aHR 2.17; 1.30-3.60); elevated NT-proBNP aHR 1.97; 1.17-3.33); or no elevated marker (reference). CONCLUSION: Higher plasma levels of IGFBP-7 were strongly and independently associated with CHF hospitalization in AF patients. The prognostic information provided by IGFBP-7 was additive to that of NT-proBNP.
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Authors | Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Michael Kühne, Nicolas Rodondi, Jürg H Beer, Peter Ammann, Giorgio Moschovitis, Leo H Bonati, Manuel R Blum, Peter Kastner, Fiona Baguley, Christian Sticherling, Stefan Osswald, David Conen, BEAT-AF and Swiss-AF Investigators |
Journal | Heart rhythm
(Heart Rhythm)
Vol. 18
Issue 4
Pg. 512-519
(04 2021)
ISSN: 1556-3871 [Electronic] United States |
PMID | 33278630
(Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Insulin-Like Growth Factor Binding Proteins
- insulin-like growth factor binding protein-related protein 1
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Topics |
- Aged
- Atrial Fibrillation
(blood, complications)
- Biomarkers
(blood)
- Disease Progression
- Female
- Follow-Up Studies
- Heart Failure
(blood, complications, therapy)
- Hospitalization
(statistics & numerical data)
- Humans
- Insulin-Like Growth Factor Binding Proteins
(blood)
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
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