EZH2 is a potential prognostic predictor of glioma.

Abstract

The enhancer of zeste homologue 2 (EZH2) is a histone H3 lysine 27 methyltransferase that promotes tumorigenesis in a variety of human malignancies by altering the expression of tumour suppressor genes. To evaluate the prognostic value of EZH2 in glioma, we analysed gene expression data and corresponding clinicopathological information from the Chinese Glioma Genome Atlas, the Cancer Genome Atlas and GTEx. Increased expression of EZH2 was significantly associated with clinicopathologic characteristics and overall survival as evaluated by univariate and multivariate Cox regression. Gene Set Enrichment Analysis revealed an association of EZH2 expression with the cell cycle, DNA replication, mismatch repair, p53 signalling and pyrimidine metabolism. We constructed a nomogram for prognosis prediction with EZH2, clinicopathologic variables and significantly correlated genes. EZH2 was demonstrated to be significantly associated with several immune checkpoints and tumour-infiltrating lymphocytes. Furthermore, the ESTIMATE and Timer Database scores indicated correlation of EZH2 expression with a more immunosuppressive microenvironment for glioblastoma than for low grade glioma. Overall, our study demonstrates that expression of EZH2 is a potential prognostic molecular marker of poor survival in glioma and identifies signalling pathways and immune checkpoints regulated by EHZ2, suggesting a direction for future application of immune therapy in glioma.

• Authors: Yi-Nan Chen, Shi-Qiang Hou, Rui Jiang, Jun-Long Sun, Chuan-Dong Cheng, Zhong-Run Qian
• Journal: Journal of cellular and molecular medicine (J Cell Mol Med) Vol. 25 Issue 2 Pg. 925-936 (01 2021) ISSN: 1582-4934 [Electronic] England
• PMID: 33277782 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Chemical References

• EZH2 protein, human
• Enhancer of Zeste Homolog 2 Protein

Topics

• Brain Neoplasms (genetics, immunology, metabolism, pathology)
• Cell Line, Tumor
• Enhancer of Zeste Homolog 2 Protein (genetics, metabolism)
• Gene Expression Regulation, Neoplastic
• Glioma (genetics, immunology, metabolism, pathology)
• Humans
• Immunity
• Nomograms
• Prognosis
• Signal Transduction (genetics)
• Survival Analysis
• Tumor Microenvironment (genetics)