Abstract | OBJECTIVE: The investigation of the effect of carvone (a natural monoterpene) on liver damage caused by chronic immobilisation. METHODS: Male Wistar rats were divided into four groups: control, carvone, stress, and stress- carvone. To induce stress, rats were placed in a restrainer (6 h/21 day) and carvone was treated by gavage at a dose of 20 mg/kg. RESULTS: CONCLUSION: It is concluded that carvone has effectively prevented chronic immobilisation-induced liver injury, most probably through its antioxidant and anti-inflammatory capabilities.
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Authors | Masoumeh Asle-Rousta, Rahim Amini, Safieh Aghazadeh |
Journal | Archives of physiology and biochemistry
(Arch Physiol Biochem)
Vol. 129
Issue 3
Pg. 597-602
(Jun 2023)
ISSN: 1744-4160 [Electronic] England |
PMID | 33270467
(Publication Type: Journal Article)
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Chemical References |
- carvone
- Antioxidants
- Glutathione
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Topics |
- Rats
- Male
- Animals
- Rats, Wistar
- Liver
(metabolism)
- Inflammation
(metabolism)
- Oxidative Stress
- Antioxidants
(pharmacology, metabolism)
- Glutathione
(metabolism)
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