Impaired cholesterol efflux capacity in patients with Helicobacter pylori infection and its relation with inflammation.

Abstract

BACKGROUND:

Gut microorganisms are associated with atherosclerosis and related cardiovascular disease. Helicobacter pylori (H. pylori) infection is associated with dyslipidemia and inflammation contributing to the progression of atherosclerosis.

OBJECTIVE:

Several studies have reported reduced HDL-C levels in H. pylori infected patients, but HDL cholesterol efflux capacity (CEC) as the most important function of HDL has not been evaluated yet.

METHODS:

This cross-sectional study was conducted with 44 biopsy confirmed H. pylori patients and 43 controls. ABCA1-mediated, non-ABCA1 and total CEC were measured in ApoB-depleted serum and levels of ApoA-I, ApoB and hsCRP were estimated using ELISA technique.

RESULTS:

Total and ABCA1 mediated-CEC were reduced in patients compared to controls, independent of age, sex, body mass index and HDL-C (p < 0.001), while non-ABCA1 CEC indicated no significant change between the groups. In addition, patients showed lower serum levels of ApoA-I but increased levels of hsCRP when compared to controls. Total CEC and ABCA1-mediated CEC positively correlated with ApoA-I and HDL-C, furthermore, ABCA1-mediated CEC as well as ApoA-I inversely correlated with hsCRP.

CONCLUSION:

The results of the present study indicate reduced CECs in H. pylori infected patients, especially ABCA1-mediated CEC which is associated with decreased ApoA-I and increased inflammation.

• Authors: Soudabeh Fallah, Gunther Marsche, Maryam Mohamadinarab, Samaneh Mohassel Azadi, Hooman Ghasri, Reza Fadaei, Nariman Moradi
• Journal: Journal of clinical lipidology (J Clin Lipidol) 2021 Jan-Feb Vol. 15 Issue 1 Pg. 218-226.e1 ISSN: 1933-2874 [Print] United States
• PMID: 33250430 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Helicobacter Infections
• Helicobacter pylori
• Humans
• Middle Aged