Abstract | INTRODUCTION: Respiratory syncytial virus (RSV) is considered a major pathogen that causes acute influenza-like illness. The objective of this study was to compare the clinical outcomes of patients with laboratory-confirmed RSV and patients with influenza infection. METHODS: Adults hospitalized in Beilinson Hospital (October 2017-April 2018) with laboratory-confirmed RSV or influenza were included. The primary outcome was the composite of RSV/ influenza complications: 30-day mortality, pneumonia, mechanical ventilation, vasopressor support, intensive care unit admission, and myocarditis/ encephalitis. Secondary outcomes were individual components of the primary outcome, 90-day mortality, 90-day readmission, and length of hospital stay. RESULTS: A total of 639 patients with RSV (n = 113) and influenza (n = 526) were included. The composite primary outcome was 21.4% (136/633), and was higher in RSV patients (30% (34/113) vs 19% (102/526), p = 0.002). Pneumonia was more common in RSV patients (21.2% (24/113) vs 9.1% (48/526), p = 0.001). On multivariable analysis, hypoalbuminemia (odds ratio (OR) 3.3, 95% confidence interval (CI) 2.1-5.3, p < 0.001), reduced room-air saturation (OR 1.1, 95% CI 1.02-1.1, p = 0.001), and infection with RSV (OR 1.67, 95% CI 1.01-2.76, p = 0.046) were predictors of complications. CONCLUSIONS:
RSV infection in hospitalized adults resulted in serious respiratory illness with complications that are comparable to those caused by influenza.
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Authors | Alaa Atamna, Tanya Babich, Dafi Froimovici, Dafna Yahav, Nadav Sorek, Haim Ben-Zvi, Leonard Leibovici, Jihad Bishara, Tomer Avni |
Journal | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
(Int J Infect Dis)
Vol. 103
Pg. 489-493
(Feb 2021)
ISSN: 1878-3511 [Electronic] Canada |
PMID | 33249288
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Topics |
- Aged
- Aged, 80 and over
- Female
- Hospitalization
- Humans
- Influenza, Human
(epidemiology, mortality, pathology, virology)
- Inpatients
- Male
- Middle Aged
- Morbidity
- Respiratory Syncytial Virus Infections
(epidemiology, mortality, pathology, virology)
- Respiratory Syncytial Virus, Human
(isolation & purification)
- Retrospective Studies
- Seasons
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