Abstract | BACKGROUND: OBJECTIVES: METHODS: Specific binding of the 18 kDa translocator protein tracer 18 F-GE-180 was determined by serial PET during pharmacological depletion of microglia in a 4-repeat tau mouse model. The 18 kDa translocator protein PET was performed in 30 patients with corticobasal syndrome (68 ± 9 years, 16 women) and 14 patients with progressive supranuclear palsy (69 ± 9 years, 8 women), and 13 control subjects (70 ± 7 years, 7 women). Group comparisons and associations with parameters of disease progression were assessed by region-based and voxel-wise analyses. RESULTS: CONCLUSIONS: Our data indicate that 18 F-GE-180 PET detects microglial activation in the brain of patients with 4-repeat tauopathy, fitting to predilection sites of the phenotype. The 18 kDa translocator protein PET has a potential for monitoring neuroinflammation in 4-repeat tauopathies. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Authors | Carla Palleis, Julia Sauerbeck, Leonie Beyer, Stefanie Harris, Julia Schmitt, Estrella Morenas-Rodriguez, Anika Finze, Alexander Nitschmann, Francois Ruch-Rubinstein, Florian Eckenweber, Gloria Biechele, Tanja Blume, Yuan Shi, Endy Weidinger, Catharina Prix, Kai Bötzel, Adrian Danek, Boris-Stephan Rauchmann, Sophia Stöcklein, Simon Lindner, Marcus Unterrainer, Nathalie L Albert, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Peter Bartenstein, Jochen Herms, Robert Perneczky, Christian Haass, Johannes Levin, Günter U Höglinger, Matthias Brendel |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 36
Issue 4
Pg. 883-894
(04 2021)
ISSN: 1531-8257 [Electronic] United States |
PMID | 33245166
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
Chemical References |
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Topics |
- Aged
- Alzheimer Disease
- Animals
- Brain
(diagnostic imaging, metabolism)
- Cross-Sectional Studies
- Female
- Humans
- Male
- Mice
- Middle Aged
- Supranuclear Palsy, Progressive
(diagnostic imaging, genetics)
- Tauopathies
(diagnostic imaging, genetics)
- tau Proteins
(genetics, metabolism)
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