Verminoside from Pseudolysimachion rotundum var. subintegrum sensitizes cisplatin-resistant cancer cells and suppresses metastatic growth of human breast cancer.

Abstract	Breast cancer is one of the most common cancers in women and is associated with a high mortality rate. The majority of deaths resulting from breast cancer are attributable to metastatic growth; in addition, chemoresistance is a major concern in the treatment of patients with breast cancer. However, limited drugs are available for the treatment of metastatic breast cancer. In this study, the chemoadjuvant effects of a methanolic extract from the leaves of Pseudolysimachion rotundum var. subintegrum (NC13) and an active component isolated from the plant, verminoside (Vms), were evaluated. Furthermore, their potent anti-metastatic activities were validated in vitro and in vivo in animal models. The anti-metastatic and chemosensitizing activities of NC13 and Vms on cisplatin treatment were found to be partly mediated by suppression of the epithelial-mesenchymal transition of cancer cells. Collectively, our results implied that NC13 and its bioactive component Vms could be developed as effective chemoadjuvants in combination with conventional therapeutics.
Authors	Changhu Lee, Hyung Won Ryu, Sahee Kim, Min Kim, Sei-Ryang Oh, Kyung-Seop Ahn, Jiyoung Park
Journal	Scientific reports (Sci Rep) Vol. 10 Issue 1 Pg. 20337 (11 23 2020) ISSN: 2045-2322 [Electronic] England
PMID	33230126 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adjuvants, Pharmaceutic Antineoplastic Agents Iridoids Plant Extracts verminoside Cisplatin
Topics	Adjuvants, Pharmaceutic (pharmacology) Allografts Animals Antineoplastic Agents (administration & dosage) Breast Neoplasms (diet therapy, drug therapy, metabolism, pathology) Cell Survival (drug effects) Cisplatin (administration & dosage) Diet Disease Models, Animal Drug Resistance, Neoplasm (drug effects) Epithelial-Mesenchymal Transition (drug effects) Female Humans Iridoids (pharmacology) MCF-7 Cells Male Mice Mice, Inbred BALB C Neoplasm Metastasis (drug therapy) Phytotherapy (methods) Plant Extracts (pharmacology) Plant Leaves (chemistry) Veronica (chemistry)

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