Abstract | INTRODUCTION: RESEARCH DESIGN AND METHODS: We investigated longitudinal data from participants of the 'Tübinger Evaluation of Risk Factors for Early Detection of Neurodegeneration' Study. Subjects underwent a neurocognitive assessment battery (CERAD Plus battery; Consortium to Establish a Registry for Alzheimer's Disease) at baseline and followed every 2 years (median follow-up 4.0 Q1-3: 2.2-4.3 years). Subjects within a pre-diabetic glycated hemoglobin range of 5.6%-6.5% underwent 5-point 75 g oral glucose tolerance tests (OGTTs) with assessment of insulin sensitivity and insulin secretion (n=175). Subjects with newly diagnosed diabetes mellitus or with major depressivity (Beck Depression Inventory >20) were excluded (n=15). Data were analyzed by mixed models using sex, age and glycemic trait as fixed effects. Subject and time since first measurement were used as random effects. RESULTS:
Insulin sensitivity was positively associated with the CERAD sum score (higher is better) in a time-dependent manner (p=0.0057). This result is mainly driven by a steeper decrease in the memory domain associated with lower insulin sensitivity (p=0.029). The interaction between age and insulin sensitivity was independent of glycemia (p=0.02). There was also no association between insulin secretion and cognition. CONCLUSIONS:
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Authors | Caroline Willmann, Kathrin Brockmann, Robert Wagner, Stephanie Kullmann, Hubert Preissl, Günter Schnauder, Walter Maetzler, Thomas Gasser, Daniela Berg, Gerhard W Eschweiler, Florian Metzger, Andreas J Fallgatter, Hans-Ulrich Häring, Andreas Fritsche, Martin Heni |
Journal | BMJ open diabetes research & care
(BMJ Open Diabetes Res Care)
Vol. 8
Issue 2
(11 2020)
ISSN: 2052-4897 [Electronic] England |
PMID | 33203727
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Topics |
- Cognitive Dysfunction
(diagnosis)
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(complications, diagnosis)
- Humans
- Insulin Resistance
- Prediabetic State
(complications, diagnosis)
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