Iron Serum Markers Profile in Frontotemporal Lobar Degeneration.

Abstract

Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative syndrome. Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state. In this study we assessed Fe, transferrin (Trf), ferritin, Cp specific activity (eCp/iCp), Cp/Trf ratio, and Trf saturation in 60 FTLD patients and 43 healthy controls, and discussed the results in relation to Cu homeostasis. The significant decrease of the eCp/iCp in the FTLD patients supports the involvement of Fe imbalance in the onset and progression of FTLD.

• Authors: Anastasia De Luca, Silvia Fostinelli, Clarissa Ferrari, Giuliano Binetti, Luisa Benussi, Barbara Borroni, Luisa Rossi, Mauro Rongioletti, Roberta Ghidoni, Rosanna Squitti
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 78 Issue 4 Pg. 1373-1380 ( 2020) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 33185611 (Publication Type: Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Transferrin
• Ferritins
• Iron
• Ceruloplasmin

Topics

• Aged
• Aphasia, Primary Progressive (blood, metabolism)
• Case-Control Studies
• Ceruloplasmin (metabolism)
• Female
• Ferritins (blood)
• Frontotemporal Dementia (blood, metabolism)
• Frontotemporal Lobar Degeneration (blood)
• Humans
• Iron (blood, metabolism)
• Male
• Middle Aged
• Transferrin (metabolism)