Abstract | BACKGROUND: OBJECTIVES: ANIMALS: Eighteen dogs with AD. METHODS AND MATERIALS: This study was a randomized, double-blinded, placebo-controlled trial. All dogs were treated with oclacitinib (0.4-0.6 mg/kg twice daily for 14 days, then once daily for 14 days) and randomized to receive either HCA spray or placebo spray, applied once daily for seven days then every other day through to Day (D)28. Clinical assessments included the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-4) and the pruritus Visual Analog Scale ( PVAS) every seven days, and blood and urine tests every 14 days. RESULTS: The mean CADESI-4 and PVAS scores were significantly reduced on D7 and D14 compared to D0 in both groups (P < 0.05). From D14 to D21, CADESI-4 and PVAS scores were significantly increased in the placebo group (P < 0.005), and not in the HCA-treated group. The mean reduction from baseline of the HCA-treated group was significantly higher than that of the placebo group for the PVAS and CADESI-4 on D21 (59.9% versus 27.6%, P = 0.0216) and D28 (56.0% versus 30.5%, P = 0.0109), respectively. One dog in the HCA-treated group was withdrawn as a consequence of developing diarrhoea. CONCLUSION: Topical application of 0.0584% HCA spray may be useful for preventing exacerbation of pruritus and clinical lesions when tapering oclacitinib therapy in dogs with AD.
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Authors | Junko Takahashi, Satoko Kanda, Ichiro Imanishi, Tadashi Hisano, Teruyasu Fukamachi, Norihito Taguchi, Shoko Momiyama, Satoshi Nishiyama, Tomoki Motegi, Keita Iyori |
Journal | Veterinary dermatology
(Vet Dermatol)
Vol. 32
Issue 2
Pg. 119-e25
(Apr 2021)
ISSN: 1365-3164 [Electronic] England |
PMID | 33185330
(Publication Type: Journal Article, Randomized Controlled Trial, Veterinary)
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Copyright | © 2020 the European Society of Veterinary Dermatology and the American College of Veterinary Dermatology. |
Chemical References |
- Dermatologic Agents
- Pyrimidines
- Sulfonamides
- hydrocortisone aceponate
- oclacitinib
- Hydrocortisone
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Topics |
- Animals
- Dermatitis, Atopic
(drug therapy, veterinary)
- Dermatologic Agents
(adverse effects)
- Dog Diseases
(drug therapy)
- Dogs
- Double-Blind Method
- Hydrocortisone
(analogs & derivatives)
- Pyrimidines
- Sulfonamides
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