Abstract | BACKGROUND: METHODS: Six-day-old mice received anesthesia with 3% sevoflurane 2 hours daily on postnatal days 6, 9, and 12. Alpha-2 adrenergic receptor agonist dexmedetomidine and clonidine were used to treat the mice with and without the α-2 adrenergic receptor antagonist yohimbine. Mouse hippocampi were harvested and subjected to western blot analysis. The New Object Recognition Test and Morris Water Maze were used to measure cognitive function. We analyzed the primary outcomes by using 2- and 1-way analysis of variance (ANOVA) and Mann-Whitney U test to determine the effects of sevoflurane on the amounts of phosphorylated tau, postsynaptic density-95, and cognitive function in young mice after the treatments with dexmedetomidine, clonidine, and yohimbine. RESULTS: CONCLUSIONS:
|
Authors | Mingyang Sun, Yuanlin Dong, Mengzhu Li, Yiying Zhang, Feng Liang, Jiaqiang Zhang, Sulpicio G Soriano, Zhongcong Xie |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 132
Issue 3
Pg. 878-889
(03 01 2021)
ISSN: 1526-7598 [Electronic] United States |
PMID | 33181559
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Copyright | Copyright © 2020 International Anesthesia Research Society. |
Chemical References |
- Adrenergic alpha-2 Receptor Agonists
- Mapt protein, mouse
- Receptors, Adrenergic, alpha-2
- tau Proteins
- Sevoflurane
- Dexmedetomidine
- Clonidine
|
Topics |
- Adrenergic alpha-2 Receptor Agonists
(pharmacology)
- Age Factors
- Animals
- Behavior, Animal
(drug effects)
- Clonidine
(pharmacology)
- Cognition
(drug effects)
- Cognitive Dysfunction
(chemically induced, metabolism, prevention & control, psychology)
- Dexmedetomidine
(pharmacology)
- Disease Models, Animal
- Exploratory Behavior
(drug effects)
- Female
- Hippocampus
(drug effects, metabolism)
- Male
- Mice, Inbred C57BL
- Morris Water Maze Test
(drug effects)
- Phosphorylation
- Receptors, Adrenergic, alpha-2
(drug effects, metabolism)
- Sevoflurane
- tau Proteins
(metabolism)
- Mice
|