Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review.

Abstract

Glioblastoma Multiforme (GBM) is a poorly curable brain tumor because of its extremely invasive nature. Curcuminoids, as potential phytochemicals extracted from Curcuma Longa L., have been documented for their chemopreventive and antitumor activities against several types of malignancies. These compounds exert these effects via modulation of multiple signaling pathways and molecular targets at different stages of tumor progression, proliferation, and metastasis. In experimental studies, curcuminoids have demonstrated promising therapeutic benefits to overcome GBM. Curcuminoids have been shown to exert their anti-GBM effects through regulation of angiogenesis, apoptosis, autophagy, metastasis, invasion, as well as potential molecular targets, including receptor tyrosine kinases, Sonic Hedgehog, and NF-κB. This study reviews the observations regarding the impact of curcumin and its derivatives on GBM and the potential of translating the research findings into the clinic.

• Authors: Amir R Afshari, Mohammad Jalili-Nik, Farzaneh Abbasinezhad-Moud, Hossein Javid, Mohammad Karimi, Hamid Mollazadeh, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 28 Issue 39 Pg. 8116-8138 ( 2021) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 33176632 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Diarylheptanoids
• Hedgehog Proteins
• Curcumin

Topics

• Brain Neoplasms
• Cell Line, Tumor
• Cell Proliferation
• Curcumin (pharmacology, therapeutic use)
• Diarylheptanoids
• Glioblastoma (drug therapy)
• Hedgehog Proteins
• Humans