Abstract | BACKGROUND: Transplant recipients are at high risk for infections. However, donor-recipient transmission of multidrug-resistant organisms (MDROs) remains mostly unaddressed in the protocols of pre-transplant infection and colonization screening. Vancomycin-resistant enterococci (VRE) are MDROs that colonize the gastrointestinal tract and are associated with a significant burden of disease. Besides the high mortality of invasive VRE infections, chronic colonization leads to costly isolation measures in the hospital setting. Whereas most post- transplantation VRE infections are endogenous and thus preceded by colonization of the recipient, conclusive evidence of VRE transmission via allograft in the context of intestinal transplantation is lacking. CASE PRESENTATION: CONCLUSIONS: This case underlines the relevance of donor-recipient VRE transmission and invasive infection in the context of intestinal transplantation, highlighting the need for preoperative MDRO screening that facilitates the prompt and effective treatment of possible infections as well as the timely establishment of contact precautions to prevent further spread.
|
Authors | Carlos L Correa-Martínez, Felix Becker, Vera Schwierzeck, Alexander Mellmann, Jens G Brockmann, Stefanie Kampmeier |
Journal | Antimicrobial resistance and infection control
(Antimicrob Resist Infect Control)
Vol. 9
Issue 1
Pg. 180
(11 07 2020)
ISSN: 2047-2994 [Electronic] England |
PMID | 33160394
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Bacteremia
(etiology)
- Drug Resistance, Multiple, Bacterial
- Gram-Positive Bacterial Infections
(transmission)
- Humans
- Intestines
(transplantation)
- Male
- Middle Aged
- Postoperative Complications
(etiology)
- Tissue Donors
- Vancomycin-Resistant Enterococci
|