Abstract |
To further define optimal combinations of antiemetics, high-dose metoclopramide and lorazepam (M+L) were compared with prochlorperazine and lorazepam (P+L) in a randomized, double-blind, cross-over study. Both patient and observer assessments were documented in 66 patients receiving cisplatin and noncisplatin chemotherapy. M+L significantly reduced the severity of vomiting (P = 0.01), duration of vomiting (P = 0.05), and number of vomiting episodes (P = 0.003). Comparing the severity or duration of nausea, M+L and P+L were not significantly different. M+L significantly reduced severity of vomiting (P = 0.005) and number of vomiting episodes (P = 0.03) in the cisplatin subset. The number of vomiting episodes was also reduced in the noncisplatin subset (P = 0.03). When asked to nominate a preferred regimen, 41% of patients preferred P+L, 35% preferred M+L, and 24% rated them equally. M+L was associated with significantly more anxiety and less sedation than P+L. Patient assessments produced similar results to observer assessments but gave a broader understanding of our patients' tolerance to chemotherapy. M+L is a superior regimen in controlling vomiting induced by chemotherapy.
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Authors | J F Bishop, M Wolf, J P Matthews, K Scott, S Ackland, K Yuen, C Morton, B L Hillcoat, I A Cooper |
Journal | Cancer treatment reports
(Cancer Treat Rep)
Vol. 71
Issue 11
Pg. 1007-11
(Nov 1987)
ISSN: 0361-5960 [Print] United States |
PMID | 3315193
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Metoclopramide
- Lorazepam
- Prochlorperazine
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(adverse effects)
- Clinical Trials as Topic
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Lorazepam
(administration & dosage, therapeutic use)
- Male
- Metoclopramide
(administration & dosage, therapeutic use)
- Middle Aged
- Nausea
(chemically induced, prevention & control)
- Prochlorperazine
(administration & dosage, therapeutic use)
- Random Allocation
- Vomiting
(chemically induced, prevention & control)
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