Abstract | BACKGROUND: METHODS: RESULTS: At baseline, ADPKD patients demonstrated a higher copeptin concentration in comparison with healthy controls, while urinary excretion of cortisol and cortisone was lower (medians of 0.23 vs. 0.34 μmol/24 h, p = 0.007, and 0.29 vs. 0.53 μmol/24 h, p < 0.001, respectively). There were no differences in cortisol and cortisone excretion compared to IgA nephropathy patients. Cortisol, cortisone, and total glucocorticoid excretions correlated with kidney function (R = 0.37, 0.58, and 0.19, respectively; all p < 0.05). Despite that V2RA treatment resulted in a 3-fold increase in copeptin, only cortisone excretion increased (median of 0.44 vs. baseline 0.29 μmol/24 h, p < 0.001), whereas no changes in cortisol or total glucocorticoid excretion were observed. CONCLUSIONS: Increased concentration of vasopressin in ADPKD patients at baseline and during V2RA treatment does not result in activation of the HPA axis. The impaired glucocorticoid production in these patients is related to their degree of kidney function impairment.
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Authors | Judith E Heida, Isidor Minović, Martijn van Faassen, Ido P Kema, Wendy E Boertien, Stephan J L Bakker, André P van Beek, Ron T Gansevoort |
Journal | American journal of nephrology
(Am J Nephrol)
Vol. 51
Issue 11
Pg. 861-870
( 2020)
ISSN: 1421-9670 [Electronic] Switzerland |
PMID | 33147589
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2020 The Author(s) Published by S. Karger AG, Basel. |
Chemical References |
- AVPR2 protein, human
- Antidiuretic Hormone Receptor Antagonists
- Glycopeptides
- Receptors, Vasopressin
- copeptins
- Vasopressins
- Cortisone
- Hydrocortisone
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Topics |
- Adult
- Aged
- Antidiuretic Hormone Receptor Antagonists
(administration & dosage, adverse effects)
- Case-Control Studies
- Cortisone
(metabolism, urine)
- Female
- Glomerular Filtration Rate
(drug effects, physiology)
- Glomerulonephritis, IGA
(metabolism, urine)
- Glycopeptides
(urine)
- Humans
- Hydrocortisone
(metabolism, urine)
- Hypothalamo-Hypophyseal System
(drug effects, metabolism)
- Male
- Middle Aged
- Pituitary-Adrenal System
(drug effects, metabolism)
- Polycystic Kidney, Autosomal Dominant
(diagnosis, drug therapy, metabolism, urine)
- Receptors, Vasopressin
(metabolism)
- Renal Elimination
(drug effects)
- Severity of Illness Index
- Vasopressins
(metabolism, urine)
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