Abstract | PURPOSE: METHODS: Data of 34 high-risk pregnancies in 23 women presenting at the University hospitals of Minden and Jena from 01-Jun-2007 to 01-Jun-2020 were collected. Reasons defining high-risk ET pregnancy in all 23 patients were: Thrombosis (n = 9) or severe hemorrhage (n = 2) in history, platelet count ≥ 1500 × 103/µl (n = 8) or severe microcirculatory disturbances not completely responding to ASA (n = 4). RESULTS: Without the use of IFN, live birth rate was 60% (6/10), however, after the use of IFN live birth rate increased to 73.5% (25/34 pregnancies). Nine pregnancies ended in miscarriages (9/34; 26.5%); all of them spontaneous abortions. Live birth rate significantly improved with ASA (90% versus 50%, p = 0.0168), however, if ASA and LMWH was added (n = 14), live birth rate was 100%. IFN compound (PEGylated versus standard IFN) and JAK2-driver mutation had no impact on pregnancy outcome. One major maternal complication occurred as a major peripartal bleeding after abortion curettage. CONCLUSION: IFN was associated with an encouraging live birth rate of 73.5% with no fatal maternal events and manageable side effects.
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Authors | Lukas Schrickel, Florian H Heidel, Parvis Sadjadian, Tatjana Becker, Vera Kolatzki, Andreas Hochhaus, Martin Griesshammer, Kai Wille, German Study Group MPN, GSG-MPN |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 147
Issue 5
Pg. 1481-1491
(May 2021)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 33140210
(Publication Type: Journal Article)
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Chemical References |
- Heparin, Low-Molecular-Weight
- Interferon-alpha
- Janus Kinase 2
- Aspirin
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Topics |
- Abortion, Spontaneous
(metabolism, prevention & control)
- Adult
- Aspirin
(therapeutic use)
- Female
- Heparin, Low-Molecular-Weight
(therapeutic use)
- Humans
- Interferon-alpha
(therapeutic use)
- Janus Kinase 2
(metabolism)
- Platelet Count
(methods)
- Pregnancy
- Pregnancy Outcome
- Pregnancy, High-Risk
(drug effects, metabolism)
- Retrospective Studies
- Thrombocythemia, Essential
(drug therapy, metabolism)
- Young Adult
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