Abstract | BACKGROUND: METHODS: We conducted a prospective cohort study of 380,087 adults aged 40-69 years in the UK Biobank. Serum high-density cholesterol, low-density cholesterol, total cholesterol, triglycerides, and apolipoprotein A and B were measured. We used Cox proportional hazard models to estimate the multivariable hazard ratios (HRs) of CRC according to one standard deviation (SD) increment in serum lipids. We conducted subgroup analysis by tumour anatomical subsites. RESULTS: During a median of 10.3 years of follow-up, we documented 2667 incident CRC cases. None of the lipid biomarkers was associated with the risk of CRC after adjusting for potential confounding factors, including body mass index and waist circumference. When assessed by cancer subsites, serum triglycerides was associated with an increased risk of cancer in the caecum and transverse colon, with the HR of 1.12 (95% CI, 1.00-1.25) and 1.29 (95% CI, 1.09-1.53), respectively; and apolipoprotein A was associated with a lower risk of hepatic flexure cancer (HR, 0.73, 95% CI, 0.56-0.96). CONCLUSIONS:
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Authors | Zhe Fang, Mingming He, Mingyang Song |
Journal | British journal of cancer
(Br J Cancer)
Vol. 124
Issue 3
Pg. 663-670
(02 2021)
ISSN: 1532-1827 [Electronic] England |
PMID | 33139801
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins A
- Apolipoproteins B
- Cholesterol, HDL
- Cholesterol, LDL
- Lipids
- Triglycerides
- Cholesterol
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Topics |
- Adult
- Aged
- Apolipoproteins A
(blood)
- Apolipoproteins B
(blood)
- Body Mass Index
- Cecal Neoplasms
(blood, epidemiology, etiology)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Colon, Transverse
- Colonic Neoplasms
(blood, epidemiology, etiology)
- Colorectal Neoplasms
(blood, epidemiology, etiology)
- Female
- Humans
- Incidence
- Lipids
(blood)
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk
- Triglycerides
(blood)
- United Kingdom
(epidemiology)
- Waist Circumference
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