[A Case of Metachronous Liver Metastasis of Gallbladder Cancer Successfully Treated by Hepatectomy after Chemotherapy].

Abstract

We present the case of a 66-year-old female diagnosed with gallbladder cancer that was initially discovered with contrast enhanced computed tomography. The primary gall bladder tumor displayed heterogeneous enhancement. The patient underwent cholecystectomy with full-thickness excision of the gallbladder cancer. After 3 rounds of adjuvant chemotherapy with the oral fluoropyrimidine derivative, S-1(administered for 4 weeks at 120 mg/day and then stopped for 2 weeks), a metastasis measuring 15 mm in diameter emerged within hepatic segment 5. The chemotherapy regimen was altered to include 6 months of combination therapy with gemcitabine(1,000 mg/m2)and cisplatin(25 mg/m2)given once every week for 2 weeks and then stopped for 1 week. The hepatic metastasis decreased in size to 8 mm in diameter, and a partial liver resection was performed. After hepatectomy, the patient remains alive and without disease recurrence.

• Authors: Yukio Asano, Satoshi Arakawa, Masahiro Ito, Hiroyuki Kato, Masahiro Shimura, Chihiro Hayashi, Takayuki Ochi, Kenshiro Kamio, Toki Kawai, Hironobu Yasuoka, Takahiko Higashiguchi, Akihiko Horiguchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 47 Issue 10 Pg. 1501-1504 (Oct 2020) ISSN: 0385-0684 [Print] Japan
• PMID: 33130750 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Female
• Gallbladder Neoplasms (drug therapy, surgery)
• Hepatectomy
• Humans
• Liver Neoplasms (drug therapy, surgery)
• Neoplasm Recurrence, Local