Predictive Accuracy of Progesterone Receptor B in Young Women with Atypical Endometrial Hyperplasia and Early Endometrial Cancer Treated with Hysteroscopic Resection plus LNG-IUD Insertion.

Abstract

STUDY OBJECTIVE:

The immunohistochemical expression of isoform B of the progesterone receptor (PRB) has shown promising results in predicting the response of atypical endometrial hyperplasia (AEH) and early endometrial cancer (EEC) to conservative treatment. We aimed to calculate the accuracy of PRB as a predictive marker of conservative treatment outcome in AEH or EEC.

DESIGN:

Retrospective cohort study.

SETTING:

University of Naples Federico II, Naples, Italy.

PATIENTS:

Thirty-six consecutive premenopausal women <45 years of age with AEH (n = 29) or EEC (n = 7) conservatively treated from January 2007 to June 2018 were retrospectively assessed.

INTERVENTIONS:

All patients had been treated with hysteroscopic resection plus levonorgestrel-releasing intrauterine device insertion and followed for at least 1 year. The immunohistochemical expression of PRB was separately assessed in the glands and stroma of the lesion and dichotomized as "weak" or "normal."

MEASUREMENT AND MAIN RESULTS:

The treatment outcomes considered were (1) treatment failure (i.e., a combined outcome including no regression or recurrence); (2) no regression; and (3) recurrence. The predictive accuracy of PRB immunohistochemistry was assessed by calculating sensitivity (SE), specificity (SP), and area under the receiver operating characteristic curve (AUC). A weak glandular PRB expression showed SE = 70%, SP = 77%, and AUC = 0.74 for treatment failure; SE = 66.7%, SP = 70%, and AUC = 0.68 for no regression; and SE = 75%, SP = 68.8%, and AUC = 0.72 for recurrence. A weak stromal PRB expression showed SE = 100%, SP = 53.8%, and AUC = 0.77 for treatment failure; SE = 100%, SP = 46.7%, and AUC = 0.73 for no regression; and SE = 100%, SP = 43.8%, and AUC = 0.72 for recurrence.

CONCLUSION:

A weak stromal PRB expression is a highly sensitive predictive marker of both no response and recurrence of AEH and EEC conservatively treated.

• Authors: Antonio Raffone, Antonio Travaglino, Francesco Maria Zullo, Annarita Gencarelli, Mariacarolina Micheli, Sergio Miranda, Pasquale De Franciscis, Luigi Insabato, Attilio Di Spiezio Sardo, Fulvio Zullo, Giuseppe Bifulco
• Journal: Journal of minimally invasive gynecology (J Minim Invasive Gynecol) Vol. 28 Issue 6 Pg. 1244-1253 (06 2021) ISSN: 1553-4669 [Electronic] United States
• PMID: 33122144 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 AAGL. Published by Elsevier Inc. All rights reserved.

Chemical References

• Receptors, Progesterone
• progesterone receptor B
• Levonorgestrel

Topics

• Endometrial Hyperplasia (surgery)
• Endometrial Neoplasms (surgery)
• Female
• Humans
• Intrauterine Devices, Medicated
• Levonorgestrel (therapeutic use)
• Neoplasm Recurrence, Local
• Receptors, Progesterone
• Retrospective Studies