CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.

Abstract

BACKGROUND:

Common malignant tumors of the urinary system include renal cell carcinoma, bladder carcinoma, and prostate cancer. The research on the CYP24A1 gene for prostate cancer is mainly concentrated in European and American populations, and there are few studies in the Chinese population. Therefore, we selected bladder cancer, prostate cancer, and renal cancer as the research objects to explore the influence of CYP24A1 on the genetic susceptibility of urinary system tumors.

MATERIALS AND METHODS:

rs6068816, rs2296241, rs2762934, and rs1570669 in 529 patients and 523 controls were genotyped via the Agena MassARRAY. Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of two SNPs with susceptibility of urinary system cancer. Database predicts the expression of the CYP24A1 gene in urinary system cancer.

RESULTS:

Individuals with the AG genotype of CYP24A1 rs1570669 has a 28% lower risk of developing urinary system tumors (OR = 0.72, 95% CI: 0.56-1.13, p = 0.016) and has a 31% lower risk of developing renal cancer (OR = 0.69, 95% CI: 0.51-0.92, p = 0.012).

CONCLUSIONS:

CYP24A1 rs1570669 may play an important role in the susceptibility of tumors of the urinary system and renal cancer.

• Authors: Yao Sun, Xiang Wang, Jiamin Wu, Zichao Xiong, Haiyue Li, Yuanwei Liu, Jianfeng Liu, Yipeng Ding, Tianbo Jin
• Journal: Public health genomics (Public Health Genomics) Vol. 23 Issue 5-6 Pg. 200-209 ( 2020) ISSN: 1662-8063 [Electronic] Switzerland
• PMID: 33113544 (Publication Type: Journal Article)
• Copyright: © 2020 S. Karger AG, Basel.

Chemical References

• CYP24A1 protein, human
• Vitamin D3 24-Hydroxylase

Topics

• Aged
• Asian People (genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Genetic Variation
• Genotype
• Humans
• Kidney Neoplasms (genetics)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Polymorphism, Single Nucleotide
• Risk Factors
• Urologic Neoplasms (genetics)
• Vitamin D3 24-Hydroxylase (genetics)