Abstract | INTRODUCTION: RESEARCH DESIGN AND METHODS: We conducted a population-based study, recruiting 1030 individuals (average age 54.4±0.5 years), in 2017, to participate in our Iwaki project. After initial screening by fasting blood glucose and glycohemoglobin A1c (HbA1c) measurements, the subjects were categorized into control (n=894), type 2 diabetes (n=81), and impaired fasting glucose (n=55) groups. Clinical data were gathered, and relationships between pain threshold from intraepidermal electrical stimulation (PINT) and DPN were examined by analysis of variance, post hoc test, and χ2 tests to study correlations among and between groups of the clinical data and DPN. RESULTS: Univariate linear regression analyses showed significant correlations between PINT and serum lipopolysaccharide-binding protein (LBP) level (ß=0.1025, p=0.001). Adjustments for the clinical measurements confirmed a positive correlation (ß=0.070, p=0.034). Logistic regression analysis revealed high LBP value (>6.7 mg/dL) as a significant risk factor toward abnormal PINT (≥0.35 mA). LBP significantly correlated with the high-sensitivity C reactive protein, inflammation marker, elevated similarly in both pre-diabetic and overt-diabetic groups, compared with controls, but it did not correlate with a decreased Achilles tendon reflex. In contrast, urine 8-hydroxy-2'-deoxyguanosine, oxidative stress marker, and pentosidine, AGEs, markedly increased in individuals with type 2 diabetes with high HbA1c. CONCLUSIONS: Individuals with high LBP exhibited an elevated PINT in the Japanese population. Low level of inflammation evoked by metabolic endotoxemia is possibly implicated in the pathophysiology of SFN from pre-diabetic stage.
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Authors | Kazuhiro Kudoh, Hiroki Mizukami, Chieko Itabashi, Nobuo Fuke, Sho Osonoi, Yuki Takeuchi, Kanichiro Wada, Akiko Igawa, Saori Ogasawara, Yasuyuki Ishibashi, Kenichi Hakamada, Soroku Yagihashi, Shigeyuki Nakaji |
Journal | BMJ open diabetes research & care
(BMJ Open Diabetes Res Care)
Vol. 8
Issue 1
(10 2020)
ISSN: 2052-4897 [Electronic] England |
PMID | 33099510
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
- Acute-Phase Proteins
- Biomarkers
- Carrier Proteins
- Membrane Glycoproteins
- lipopolysaccharide-binding protein
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Topics |
- Acute-Phase Proteins
- Biomarkers
- Carrier Proteins
- Diabetes Mellitus, Type 2
(epidemiology)
- Humans
- Japan
(epidemiology)
- Membrane Glycoproteins
- Middle Aged
- Pain Threshold
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