Breast cancer in the oldest old (≥ 89 years): Tumor characteristics, treatment choices, clinical outcomes and literature review.

Abstract

INTRODUCTION:

Risk of breast cancer increases with age and very few data are available in patients older than 89.

METHODS:

A retrospective analysis on patients aged 89 and older treated between 2008 and 2019 at our certified breast center. The aim was to analyze clinical characteristics, decision-making, treatment, outcomes and open questions regarding this subpopulation for which there is a lack of guidelines.

RESULTS:

58 patients included. Tumor characteristics were analyzed, 85% patients underwent surgery of which 44% had a mastectomy. The median follow-up and overall survival were 20 and 76 months, respectively.The median survival of metastatic and non-metastatic patients were 14 and 50 months, respectively. Most patients did not receive any adjuvant treatment and among these 14% had a relapse.

CONCLUSIONS:

Elderly patients should not be under or over-treated because of their age; they represent a large heterogeneous group deserving a sub-stratification for a better tailored treatment.

• Authors: Simona Di Lascio, Enrico Tognazzo, Sara Bigiotti, Marta Bonollo, Alberto Costa, Olivia Pagani, Francesco Meani
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 47 Issue 4 Pg. 796-803 (04 2021) ISSN: 1532-2157 [Electronic] England
• PMID: 33097334 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Chemical References

• Receptors, Estrogen
• Receptors, Progesterone
• ERBB2 protein, human
• Receptor, ErbB-2

Topics

• Aged, 80 and over
• Breast Neoplasms (diagnosis, metabolism, pathology, therapy)
• Breast Neoplasms, Male (diagnosis, pathology, surgery)
• Carcinoma in Situ (diagnosis, metabolism, pathology, therapy)
• Carcinoma, Ductal, Breast (diagnosis, metabolism, secondary, therapy)
• Carcinoma, Lobular (diagnosis, metabolism, secondary, therapy)
• Chemotherapy, Adjuvant
• Clinical Decision-Making
• Disease Progression
• Female
• Follow-Up Studies
• Humans
• Male
• Mastectomy
• Neoplasm Grading
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (pathology)
• Neoplasm Staging
• Radiotherapy, Adjuvant
• Receptor, ErbB-2 (metabolism)
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Retrospective Studies
• Survival Rate
• Triple Negative Breast Neoplasms (diagnosis, pathology, therapy)