Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.

Abstract	Matrix metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins. Increased expression of MMPs have been described in traumatic brain injury (TBI) and may contribute to additional tissue injury and blood-brain barrier damage. The objectives of this study were to determine longitudinal changes in cerebrospinal fluid (CSF) concentrations of MMPs after acute TBI and in relation to clinical outcomes, with patients with idiopathic normal pressure hydrocephalus (iNPH) serving as a contrast group. The study included 33 TBI patients with ventricular CSF serially sampled, and 38 iNPH patients in the contrast group. Magnetic bead-based immunoassays were utilized to measure the concentrations of eight MMPs in ventricular human CSF. CSF concentrations of MMP-1, MMP-3 and MMP-10 were increased in TBI patients (at baseline) compared with the iNPH group (p < 0.001), while MMP-2, MMP-9 and MMP-12 did not differ between the groups. MMP-1, MMP-3 and MMP-10 concentrations decreased with time after trauma (p = 0.001-0.04). Increased concentrations of MMP-2 and MMP-10 in CSF at baseline were associated with an unfavourable TBI outcome (p = 0.002-0.02). Observed variable pattern of changes in MMP concentrations indicates that specific MMPs serve different roles in the pathophysiology following TBI, and are in turn associated with clinical outcomes.
Authors	Karolina Minta, Gunnar Brinkmalm, Faiez Al Nimer, Eric P Thelin, Fredrik Piehl, Mats Tullberg, Anna Jeppsson, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson
Journal	Scientific reports (Sci Rep) Vol. 10 Issue 1 Pg. 18075 (10 22 2020) ISSN: 2045-2322 [Electronic] England
PMID	33093584 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers Matrix Metalloproteinases
Topics	Adult Aged Biomarkers (cerebrospinal fluid) Brain Injuries, Traumatic (cerebrospinal fluid, diagnosis) Case-Control Studies Female Follow-Up Studies Humans Male Matrix Metalloproteinases (cerebrospinal fluid) Middle Aged Prognosis Prospective Studies

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